..."Looking back,
                         it's easy to see when a mistake has been made,
                   to regret a choice that seemed like a decent idea at the time,
                                                        but if we used our best judgement,
                                                                                      and listened to our hearts,
                                                 we're more likely to see that we chose wisely,
                                                        and avoided the deepest, most painful regret of them all...
                                 the regret that comes from letting something amazing pass you by."

Grey's Anatomy
Season 10, episode 13.